Regeneration of the long term denervated human muscle
نویسنده
چکیده
Light and electron microscopy and antibody for embryonic myosin show that myogenic regenerative events are present in human muscle up to 37-year postspinal cord injury. After 5 years of Functional Electrical Stimulation (FES) in the recovered muscles regenerative events are present, but at a lower rate than in longterm denervated muscles. We conclude that the FES-training of paraplegic subjects is safe (it does not induce more muscle damage/regeneration than denervation per se) and effective (the mean size of the myofibers went from 15.4 to 27.0, that is, a 76% increase after two years of FES).
منابع مشابه
Contractile Proteins Content of Long Term Permanent Denervated Human Muscle after Functional Electrical Stimulation
Severe atrophy of skeletal muscles occurs during long-term permanent denervation (LTPD). We studied 14 human muscle biopsies taken from patients suffering lower motoneuron denervation from 2 to 30 years. Patients were treated with Functional Electrical Stimulation (FES) for different periods of time (0.5 to 6 years). We describe new gel electrophoresis analyses, which allow to quantify protein ...
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